Deadline: November 16, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, and Education
Description: The purpose of this notice of funding opportunity is to invite R03 applications to support archiving and documenting existing data sets in order to enable secondary analysis of these data by the scientific community. The priority of this program is to archive data sets within the scientific mission of the NICHD; highest priority is to archive data collected with NICHD support.

Deadline: November 21, 2025
Award Amount: Up to $100,000 over two years
Match: None
Eligible Entities: Higher Education
Description: Supports member colleges and universities in expanding and strengthening existing programs that promote vocational reflection and discernment among students. Grants can be used for initiatives such as course development, faculty and staff collaboration, and integrating vocational exploration into general education or major requirements.

Deadline: November 24, 2025
Award Amount: Up to $3,000,000
Match: None
Eligible Entities: Higher Education
Description: The Materials Research Science and Engineering Centers (MRSECs) program provides sustained support of materials research and education of the highest quality while addressing fundamental problems in science and engineering.

Each MRSEC addresses research of a scope and complexity requiring the scale, synergy, and multidisciplinary provided by a campus-based research center. The MRSECs support materials research infrastructure in the United States, promote active collaboration between universities and other sectors, including industry and international organizations, and contribute to the development of a national network of university-based centers in materials research, education, and facilities.

Deadline: December 1, 2025
Award Amount: Up to $800,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, and Nonprofits
Description: This Notice of Funding Opportunity is intended to support novel environmental health research in which an unpredictable event or policy change provides a limited window of opportunity to collect human biological samples or environmental exposure data. The primary motivation of the NOFO is to understand the consequences of natural and human-made disasters, emerging environmental public health threats, and policy changes in the U.S. and abroad.

Deadline: December 2, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: Education, Nonprofits, Businesses, State, City, Township, County or Tribal Governments
Description: This Notice of Funding Opportunity invites applications that propose to develop novel research infrastructure that will advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations. This NOFO will use the NIH Phased Innovation Award (R61/R33) mechanism to provide up to 2 years of R61 support for initial developmental activities and up to 3 years of R33 support for expanded activities. Through this award, investigators will develop a sustainable research infrastructure to support projects that address key interdisciplinary aging research questions.

Deadline: December 4, 2025
Award Amount: $500,000 to $30,000,000
Match: None
Eligible Entities: Higher Education and Nonprofits
Description: Supports national-scale data systems and cyberinfrastructure that advance open, AI-driven, and data-intensive science and engineering research and education, including development, transition, and planning of integrated data services.

Deadline: December 9, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education, Nonprofits, and Business
Description: This program provides funding for three types of awards: standard individual or group research projects, mid-scale research infrastructure, and long-term efforts. It outlines requirements for proposals, including additional instructions for large or long-duration investments that may span multiple funding cycles. The purpose is to support research ranging from typical projects to significant, sustained infrastructure and long-term initiatives.

Deadline: December 31, 2025
Award Amount: Up to $1,000,000
Match: None
Eligible Entities: Environment, Education, State, City, Township, County or Tribal Governments, Nonprofits, Business
Description: Supports projects that restore aquatic habitats and improve fish passage by removing or modifying barriers, enhancing species access to critical habitats and promoting fish population conservation.

Deadline: January 6, 2026
Award Amount: Up to $300,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, Higher Education, and Water
Description: The Land and Water Conservation Fund Act of 1965 created a matching grant program to stimulate, encourage, and assist states with the acquisition, development, and expansion of quality outdoor recreation areas and facilities. LWCF is a reimbursement grant program funded by revenues generated from outer continental shelf oil and gas drilling.

Deadline: January 8, 2026
Award Amount: $150,000 to $250,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, and Nonprofits
Description: This program provides one-year, unrestricted grants along with coaching, expert support, and a national peer network to help early-stage education innovators grow their impact. It funds bold ideas that align with key investment areas such as innovative schools, learning solutions, teaching reimagined, and learning differences. The goal is to expand equitable learning opportunities and create a more just future for students.

Deadline: January 11, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: Higher Education, Nonprofits, Businesses, State, City, Township, County or Tribal Governments
Description: This Notice of Funding Opportunity supports applications to develop and implement investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or implementation research clinical trials. These trials may include ones that test different therapeutic, behavioral, and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial.

Deadline: January 20, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, and Businesses
Description: This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).

Deadline: January 20, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, Nonprofits, and Businesses
Description: This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).

This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain.

Deadline: January 21, 2026
Award Amount: Up to $75,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, and Nonprofits
Description: This program aims to prevent and reduce the use of opioids, methamphetamines, and the misuse of prescription drugs among youth aged 12–18. It supports initiatives that provide education, outreach, and intervention strategies to address substance use and promote healthy behaviors. The focus is on implementing evidence-based practices that engage youth and communities in prevention efforts.

Deadline: January 27, 2026
Award Amount: Up to $250,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, Education, and Businesses
Description: Support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. Specifically, this FOA will support the development of exportable training modules designed to enhance training of the biomedical research workforce. Responsive topics will be indicated through Notices of Special Interest released annually by NIGMS.

Deadline: February 4, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: Higher Education, Nonprofits, and Businesses
Description: The National AI Research Resource (NAIRR) program aims to build a shared national infrastructure that expands access to advanced computing, high-quality data, models, software, and training for artificial intelligence research. This Notice of Funding Opportunity invites proposals to operate and coordinate the foundational elements of NAIRR, helping to create a sustainable platform that supports broad participation in AI innovation. Applicants will play a key role in enabling researchers and educators across the country to responsibly advance AI while strengthening U.S. leadership in the field.

Deadline: March 5, 2026
Award Amount: Up to $250,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, Nonprofits, and Businesses
Description: This funding opportunity focuses on biomedical discovery and data-powered health, integrating streams of complex and interconnected research outputs that can be translated into scientific insights, clinical care, public health practices, and personal wellness to ensure the research is scalable, reproducible, and generalizable.

The scope of NLM’s interest in these research domains is broad, with emphasis on new and innovative methods and approaches to foster data driven discovery in the biomedical and clinical health sciences as well as domain-independent, scalable, and reusable approaches to discovery, curation, analysis, organization, and management of health-related data and digital objects.

Deadline: March 6, 2026
Award Amount: Up to $100,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Businesses, Education, Nonprofits, and Businesses
Description: The New Investigator Gateway Award in T1D Research is designed to support a robust pipeline of innovative projects and talented new investigators in T1D research. In addition to providing support for preliminary research, the Gateway program provides an opportunity for new Program Directors/Principal Investigators (PD/PIs) to pursue their studies within the intellectual environment of a select number of large, ongoing collaborative research programs.

Deadline: April 28, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: Tribal Governments, Nonprofits, Higher Education, and Businesses
Description: This grant aims to support projects that enhance the safety, security, and privacy of open-source ecosystems, including tools, methods, or processes that protect open source software from abuse, vulnerabilities, or privacy violations. Awards will fund work such as threat modeling, privacy enhancing technologies, secure tooling, and community governance mechanisms to strengthen open source infrastructure.

Deadline: May 7, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Businesses, Nonprofits, and Education
Description: This Trailblazer Award is an opportunity for NIH-defined New and Early Stage Investigators to pursue research programs that integrate engineering and the physical sciences with the life and/or biomedical sciences. A Trailblazer project may be exploratory, developmental, proof of concept, or high risk-high impact, and may be technology design-directed, discovery-driven, or hypothesis-driven.

Deadline: May 8, 2026
Award Amount: $1,000 to $25,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education, and Nonprofits
Description: The Native American Graves Protection and Repatriation Act of 1990 authorizes the Secretary of the Interior to make grants to museums, Indian Tribes, and Native Hawaiian organizations for the purposes of assisting in consultation, documentation, and repatriation of Native American human remains, funerary objects, sacred objects, and objects of cultural patrimony (25 U.S.C. 3008). NAGPRA Repatriation grants assist museums, Indian Tribes, and NHOs to defray costs associated with the packaging, transportation, contamination removal, reburial, and/or storage of NAGPRA human remains or cultural items. Project activities may include, but are not limited to: Travel, Transportation, Testing or decontamination, Building containers for transport, Ceremonial materials, or Staff time. See Program Overview for more details on project activities.

Deadline: Rolling
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher, Nonprofits, and Small Businesses
Description: The NSF Division of Environmental Biology (DEB) funds research and training in ecological and evolutionary biology. It supports projects investigating processes at levels from populations and species up to ecosystems and biogeographic scales. Funded work may include field, laboratory, or modeling studies, and interdisciplinary proposals crossing levels of organization or temporal/spatial scales are encouraged.

Deadline: Rolling
Award Amount: 65% discount on eligible broadband connectivity expenses for eligible rural health care providers (HCPs)
Match: None
Eligible Entities: Nonprofits, Higher Education, State, City, Township, County or Tribal Health Department/Agency
Description: The Healthcare Connect Fund (HCF) Program provides a 65% discount on eligible broadband connectivity expenses for eligible rural health care providers (HCPs). You can apply as an individual health care provider or as a consortium, i.e., a group of HCPs that can be both rural and non-rural.

Deadline: Rolling
Award Amount: Unspecified
Match: None
Eligible Entities: Higher Education and Nonprofits
Description: The Structure and Physics of the Solid Earth Program (SPSE) aims to advance fundamental knowledge about the ongoing dynamical processes over the age of the Earth that evolve the structure of planet Earth and underpin geohazards. SPSE supports research at all temporal and spatial scales, from the Earth’s core to its crust. Through laboratory, field, theoretical, and computational studies, the program encompasses a wide range of disciplines including structural geology, tectonics, and geophysics.

Deadline: Rolling
Award Amount: Unspecified
Match: None
Eligible Entities: Higher Education, Environment, and Nonprofits
Description: The Water, Landscape, and Critical Zone Processes program supports research on the Earth’s near-surface environment and how that environment responds to change. The Program focuses on the complex interplay amongst and between hydrologic, geomorphic, and geochemical processes and how they regulate the structure and function of the Earth’s near surface. These processes drive weathering and soil development, control water availability and quality, and help regulate the Earth’s climate system, all of which are important for natural resource sustainability and mitigation of natural hazards. It is expected that the research funded in this program will advance fundamental knowledge in Earth surface processes, leading to transformational discoveries in Earth Sciences.

Deadline: Rolling
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education, and Nonprofits
Description: Supports fundamental, applied, and translational research to advance STEM teaching and learning in both formal (pre-K–12) and informal settings, encouraging innovative, multidisciplinary projects that leverage emerging technologies like AI to develop tools, frameworks, and new insights in STEM education.

Deadline: December 31, 2026
Award Amount: $10,000 to $10,000,000
Match: None
Eligible Entities: Land Grant Institutions, Hispanic Serving Institutions, Nonprofits, and Businesses
Description: The AFRI Foundational and Applied Science Program supports grants in six AFRI priority areas to advance knowledge in both fundamental and applied sciences important to agriculture. The six priority areas are:

Plant Health and Production and Plant Products; Animal Health and Production and Animal Products; Food Safety, Nutrition, and Health; Bioenergy, Natural Resources, and Environment; Agriculture Systems and Technology; and Agriculture Economics and Rural Communities.

Deadline: Rolling until grant funding unavailable.
Award Amount: Unspecified; total grant funding $30,000,000
Match: None
Eligible Entities: Higher Education and Nonprofits
Description: The Plant Genome Research Program (PGRP) supports genome-scale research that addresses challenging questions of biological, societal and economic importance. PGRP encourages the development of innovative tools, technologies, and resources that empower a broad plant research community to answer scientific questions on a genome-wide scale. Emphasis is placed on the scale and depth of the question being addressed and the creativity of the approach. Data produced by plant genomics should be usable, accessible, integrated across scales, and of high impact across biology.

Training, broadening participation, and career development are essential to scientific progress and should be integrated in all PGRP-funded projects.

Deadline: Rolling
Award Amount: $100,000 to $30,000,000
Match: Yes
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, Businesses, and Higher Education
Description: Provides funding to support economic development initiatives in distressed communities. These programs aim to enhance infrastructure, promote resilience, and foster job creation through investments in public works and economic adjustment projects. Priority is given to projects that align with EDA’s investment priorities, including equity, workforce development, and environmentally sustainable development.

Deadline: Rolling
Award Amount: $50,000 to $600,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education, Nonprofits, and Business
Description: The Cyberinfrastructure for Public Access and Open Science, (CIPAOS) program within the Office of Advanced Cyberinfrastructure (OAC) aims to catalyze new and transformative socio-technical partnerships supporting research data infrastructure ecosystems across domains through early-stage collaborative activities between cyberinfrastructure researchers, scientists, research computing experts, data management experts, research labs, university libraries, and other communities of practice. The CI PAOS program supports the NSF Public Access Initiative by encouraging innovation across the CI ecosystem to address accessibility, discoverability, reliability, reproducibility, sustainability, and utility of data products in alignment with NSF and national goals for public access and open science.

Deadline: Rolling
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education, Nonprofits, and Small Businesses
Description: The Life and Environments Through Time (LET) program supports research that advances knowledge about the patterns and processes relating to the origin and evolution of Earth’s climate, environments, life, and sedimentary record. This research takes place at the molecular, local, regional, and global scales from the Archean Eon through the Holocene epoch. LET-supported research can be useful for predicting and planning for future global change, and for the maintenance and security of ecosystem services and human societies

Deadline: Rolling
Award Amount: Up to $3,000,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education Entities, Nonprofits, and Businesses
Description: The NSF STEM K-12 program in the Division of Research on Learning in Formal and Informal Settings (DRL) in the Directorate for STEM Education (EDU) supports fundamental, applied, and translational research that advances STEM teaching and learning and improves understanding of education across the human lifespan and a range of formal and informal settings.

Deadline: Rolling until grant funding unavailable.
Award Amount: $5,000 to $5,000,000
Match: None
Eligible Entities: Higher Education and Nonprofits
Description: The Division of Environmental Biology (DEB) Core supports research and training on evolutionary and ecological processes acting at the level of populations, species, communities, ecosystems, macrosystems, and biogeographic extents. DEB encourages research that elucidates fundamental principles that identify and explain the unity and diversity of life and its interactions with the environment over space and time.

Research may incorporate field, laboratory, or collection-based approaches; observational or manipulative studies; synthesis activities; phylogenetic discovery projects; or theoretical approaches involving analytical, statistical, or computational modeling. Proposals should be submitted to the core clusters (Ecosystem Science, Evolutionary Processes, Population and Community Ecology, and Systematics and Biodiversity Science).

Deadline: Rolling
Award Amount: Up to $250,000
Match: 5% non-federal share.
Eligible Entities: Tribal
Description: This program provides funding to 1994 Land Grant Institutions (Tribal Colleges) to make capital improvements to their educational facilities and to purchase equipment. Funds may be used for infrastructure improvements, to purchase equipment, and to develop essential community facilities. These community facilities include: Schools, education equipment, libraries, dorms, vehicles and major equipment, education and cultural projects, and renovations and improvements.

Deadline: Rolling
Award Amount: Unspecified amount
Match: None
Eligible Entities: K-12 Education, Higher Education, and organizations seeking to promote energy efficiency, the environment, and economic development.
Description: Continental Divide aims to serve the following counties in New Mexico: Bernalillo County, Cibola County, McKinley County, Sandoval County, Valencia County.

Continental Divide aims to support organizations that: Promote the efficient use of energy, such as weatherization or toward the planning, development or building of a renewable energy source, promote projects or activities that benefit the environment, promote projects or activities that create economic development, and/or projects or activities that benefit students in grades K-12 or students enrolled at an accredited New Mexico college or university within Continental Divide’s service territory.