Deadline: November 19, 2025
Award Amount: $25,000 to $50,000
Match: Yes
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, and Businesses
Description: Provides grants to support the development and expansion of food-related businesses and infrastructure in underserved communities. The fund aims to strengthen local food systems, increase access to healthy food, and promote economic development in rural and underserved areas of New Mexico.

Deadline: Rolling Monthly: November 30, 2025
Award Amount: $10,000
Match: None
Eligible Entities: Businesses
Description: WomensNet founded the “Amber Grant” in 1998. The grant was set up with one goal in mind: to honor the memory of a very special young woman, Amber Wigdahl, who died at just 19 years old — before realizing her business dreams.

Today, WomensNet carries on that tradition, proudly giving away at least $30,000 every month in Amber Grant money.

Deadline: December 2, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: Education, Nonprofits, Businesses, State, City, Township, County or Tribal Governments
Description: This Notice of Funding Opportunity invites applications that propose to develop novel research infrastructure that will advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations. This NOFO will use the NIH Phased Innovation Award (R61/R33) mechanism to provide up to 2 years of R61 support for initial developmental activities and up to 3 years of R33 support for expanded activities. Through this award, investigators will develop a sustainable research infrastructure to support projects that address key interdisciplinary aging research questions.

Deadline: December 9, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education, Nonprofits, and Business
Description: This program provides funding for three types of awards: standard individual or group research projects, mid-scale research infrastructure, and long-term efforts. It outlines requirements for proposals, including additional instructions for large or long-duration investments that may span multiple funding cycles. The purpose is to support research ranging from typical projects to significant, sustained infrastructure and long-term initiatives.

Deadline: December 30, 2025
Award Amount: $10,000
Match: None
Eligible Entities: Businesses
Description: This opportunity invests in women entrepreneurs building impact-driven, for-profit businesses in the U.S. Each grant cycle, one founder will receive a $10,000 unrestricted cash award — designed to fuel whatever moves your business forward, whether operations, growth, marketing, hiring, or infrastructure. This grant is open to businesses that are 100% women-owned, generating $1 million or less in annual revenue, and are legally registered in the United States. Nonbinary applicants assigned female at birth or who identify as female are also welcome to apply.

Deadline: December 31, 2025
Award Amount: Up to $1,000,000
Match: None
Eligible Entities: Environment, Education, State, City, Township, County or Tribal Governments, Nonprofits, Business
Description: Supports projects that restore aquatic habitats and improve fish passage by removing or modifying barriers, enhancing species access to critical habitats and promoting fish population conservation.

Deadline: December 31, 2025
Award Amount: Up to $5,000
Match: None
Eligible Entities: Businesses
Description: Independent retail stores or entrepreneurs who soon plan to open a retail store can win a $5,000 grant in Faire merchandise to help stock their store. Applicants need to provide a few details and submit a short video on how the grant money would help.

Deadline: January 11, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: Higher Education, Nonprofits, Businesses, State, City, Township, County or Tribal Governments
Description: This Notice of Funding Opportunity supports applications to develop and implement investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or implementation research clinical trials. These trials may include ones that test different therapeutic, behavioral, and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial.

Deadline: January 15, 2026
Award Amount: Up to $1,000,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, and Businesses
Description: The CyberTraining program aims to prepare, nurture, and grow the national scientific research workforce for creating, utilizing, and supporting advanced cyberinfrastructure (CI) to enable and potentially transform fundamental science and engineering (S&E) research and education. The program seeks to ensure broad adoption of CI tools, methods, and resources by the research community to catalyze major research advances and to enhance researchers’ abilities to lead the development of new CI.

Deadline: January 20, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, and Businesses
Description: This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).

Deadline: January 20, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, Nonprofits, and Businesses
Description: This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).

This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain.

Deadline: January 27, 2026
Award Amount: Up to $250,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, Education, and Businesses
Description: Support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. Specifically, this FOA will support the development of exportable training modules designed to enhance training of the biomedical research workforce. Responsive topics will be indicated through Notices of Special Interest released annually by NIGMS.

Deadline: February 4, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: Higher Education, Nonprofits, and Businesses
Description: The National AI Research Resource (NAIRR) program aims to build a shared national infrastructure that expands access to advanced computing, high-quality data, models, software, and training for artificial intelligence research. This Notice of Funding Opportunity invites proposals to operate and coordinate the foundational elements of NAIRR, helping to create a sustainable platform that supports broad participation in AI innovation. Applicants will play a key role in enabling researchers and educators across the country to responsibly advance AI while strengthening U.S. leadership in the field.

Deadline: March 5, 2026
Award Amount: Up to $250,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, Nonprofits, and Businesses
Description: This funding opportunity focuses on biomedical discovery and data-powered health, integrating streams of complex and interconnected research outputs that can be translated into scientific insights, clinical care, public health practices, and personal wellness to ensure the research is scalable, reproducible, and generalizable.

The scope of NLM’s interest in these research domains is broad, with emphasis on new and innovative methods and approaches to foster data driven discovery in the biomedical and clinical health sciences as well as domain-independent, scalable, and reusable approaches to discovery, curation, analysis, organization, and management of health-related data and digital objects.

Deadline: March 6, 2026
Award Amount: Up to $100,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Businesses, Education, Nonprofits, and Businesses
Description: The New Investigator Gateway Award in T1D Research is designed to support a robust pipeline of innovative projects and talented new investigators in T1D research. In addition to providing support for preliminary research, the Gateway program provides an opportunity for new Program Directors/Principal Investigators (PD/PIs) to pursue their studies within the intellectual environment of a select number of large, ongoing collaborative research programs.

Deadline: March 16, 2026
Award Amount: Up to $100,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Businesses, Nonprofits, and Education
Description: This Small Research Grant will support meritorious projects to provide needed scientific insight to improve the prevention, diagnosis, treatment, and/or care for individuals with Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). Specifically, this NOFO will support projects covering a wide range of topics related to AD/ADRD. The overall goal of this NOFO is (1) to encourage the next generation of researchers to pursue research and academic careers in AD/ADRD research; and (2) to stimulate established researchers who have not had a major award in AD/ADRD research to perform pilot studies to develop new, innovative AD/ADRD research programs that leverage and build upon their existing expertise.

Deadline: April 28, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: Tribal Governments, Nonprofits, Higher Education, and Businesses
Description: This grant aims to support projects that enhance the safety, security, and privacy of open-source ecosystems, including tools, methods, or processes that protect open source software from abuse, vulnerabilities, or privacy violations. Awards will fund work such as threat modeling, privacy enhancing technologies, secure tooling, and community governance mechanisms to strengthen open source infrastructure.

Deadline: May 7, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Businesses, Nonprofits, and Education
Description: This Trailblazer Award is an opportunity for NIH-defined New and Early Stage Investigators to pursue research programs that integrate engineering and the physical sciences with the life and/or biomedical sciences. A Trailblazer project may be exploratory, developmental, proof of concept, or high risk-high impact, and may be technology design-directed, discovery-driven, or hypothesis-driven.

Deadline: Rolling
Award Amount: $250,000 to $1,000,000
Match: Yes
Eligible Entities: Businesses and Nonprofits
Description: Provides low-interest loans to eligible commercial entities for energy efficiency upgrades. The loan proceeds can be used for energy efficiency audits, upgrades, and retrofits that improve overall energy consumption. Loans are offered at a fixed interest rate of 2% and may range from $250,000 to $1,000,000, with terms not exceeding the useful life of the project or 15 years. Applicants must demonstrate that more than 50% of their revenue is earned in New Mexico or that more than 50% of their services are provided in the state.

Deadline: Rolling
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher, Nonprofits, and Small Businesses
Description: The NSF Division of Environmental Biology (DEB) funds research and training in ecological and evolutionary biology. It supports projects investigating processes at levels from populations and species up to ecosystems and biogeographic scales. Funded work may include field, laboratory, or modeling studies, and interdisciplinary proposals crossing levels of organization or temporal/spatial scales are encouraged.

Deadline: Rolling Quarterly
Award Amount: Up to $2,500
Match: None
Eligible Entities: Businesses
Description: Provides funding each quarter to U.S.-based for-profit businesses to support expenses like rent, inventory, software, marketing, and professional development. Applicants must have been operating for at least two years, generate a minimum of $50,000 annually, and employ one to two people, including the owner.

Deadline: December 31, 2026
Award Amount: $10,000 to $10,000,000
Match: None
Eligible Entities: Land Grant Institutions, Hispanic Serving Institutions, Nonprofits, and Businesses
Description: The AFRI Foundational and Applied Science Program supports grants in six AFRI priority areas to advance knowledge in both fundamental and applied sciences important to agriculture. The six priority areas are:

Plant Health and Production and Plant Products; Animal Health and Production and Animal Products; Food Safety, Nutrition, and Health; Bioenergy, Natural Resources, and Environment; Agriculture Systems and Technology; and Agriculture Economics and Rural Communities.

Deadline: Rolling
Award Amount: $100,000 to $30,000,000
Match: Yes
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, Businesses, and Higher Education
Description: Provides funding to support economic development initiatives in distressed communities. These programs aim to enhance infrastructure, promote resilience, and foster job creation through investments in public works and economic adjustment projects. Priority is given to projects that align with EDA’s investment priorities, including equity, workforce development, and environmentally sustainable development.

Deadline: Rolling
Award Amount: $50,000 to $600,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education, Nonprofits, and Business
Description: The Cyberinfrastructure for Public Access and Open Science, (CIPAOS) program within the Office of Advanced Cyberinfrastructure (OAC) aims to catalyze new and transformative socio-technical partnerships supporting research data infrastructure ecosystems across domains through early-stage collaborative activities between cyberinfrastructure researchers, scientists, research computing experts, data management experts, research labs, university libraries, and other communities of practice. The CI PAOS program supports the NSF Public Access Initiative by encouraging innovation across the CI ecosystem to address accessibility, discoverability, reliability, reproducibility, sustainability, and utility of data products in alignment with NSF and national goals for public access and open science.

Deadline: Rolling
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education, Nonprofits, and Small Businesses
Description: The Life and Environments Through Time (LET) program supports research that advances knowledge about the patterns and processes relating to the origin and evolution of Earth’s climate, environments, life, and sedimentary record. This research takes place at the molecular, local, regional, and global scales from the Archean Eon through the Holocene epoch. LET-supported research can be useful for predicting and planning for future global change, and for the maintenance and security of ecosystem services and human societies

Deadline: Rolling
Award Amount: Up to $3,000,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education Entities, Nonprofits, and Businesses
Description: The NSF STEM K-12 program in the Division of Research on Learning in Formal and Informal Settings (DRL) in the Directorate for STEM Education (EDU) supports fundamental, applied, and translational research that advances STEM teaching and learning and improves understanding of education across the human lifespan and a range of formal and informal settings.

Deadline: Rolling Monthly
Award Amount: $500, Fellows may be eligible to receive $2,500 grant at the end of the year.
Match: None
Eligible Entities: Businesses
Description: Every month, the Freed Fellowship selects a U.S. small business owner to become a Freed Fellow. Fellow’s receive feedback and recommendations on how to grow their business. When applying, applicants must prepare to answer questions related to the 5 C’s: Context, Content, Community, Chemistry, and Commerce.

Deadline: Rolling
Award Amount: $500 to $5,500,000
Match: None
Eligible Entities: Businesses
Description: The U.S. Small Business Administration (SBA) helps small businesses get funding by setting guidelines for loans and reducing lender risk. These SBA-backed loans make it easier for small businesses to get the funding they need.

Deadline: Rolling
Award Amount: Unspecified
Match: None
Eligible Entities: Businesses
Description: In order to provide rural small businesses with increased opportunities to access capital, SBA created the 504 Loan Rural Initiative pilot program. This program waives some small business regulations in order to help rural development through the 504 Loan Program.

Deadline: Rolling
Award Amount: $25,000 to $5,000,000
Match: None
Eligible Entities: Nonprofits and Businesses
Description: B:Side assists those to gain access to SBA loans and fund, but also assists those that cannot access a traditional bank loan. B:Side offers loans to assist with working capital, debt refinance, leasehold improvements, business acquisition, purchasing equipment, inventory, and furniture, and buying, building, or renovating commercial real estate.

Deadline: Rolling
Award Amount: Unspecified amount
Match: None
Eligible Entities: K-12 Education, Higher Education, and organizations seeking to promote energy efficiency, the environment, and economic development.
Description: Continental Divide aims to serve the following counties in New Mexico: Bernalillo County, Cibola County, McKinley County, Sandoval County, Valencia County.

Continental Divide aims to support organizations that: Promote the efficient use of energy, such as weatherization or toward the planning, development or building of a renewable energy source, promote projects or activities that benefit the environment, promote projects or activities that create economic development, and/or projects or activities that benefit students in grades K-12 or students enrolled at an accredited New Mexico college or university within Continental Divide’s service territory.

Deadline: Rolling
Award Amount: Up to $150,000 worth of assistance
Match: None
Eligible Entities: Businesses
Description: The TRGR Technology Readiness Initiative provides New Mexico businesses the opportunity to work directly with scientists and engineers at Los Alamos or Sandia national laboratories to advance the maturation of patents, patent applications, and software related to an active license between the lab and business or developed under an active Cooperative Research and Development Agreement in which the business is a participant.

Deadline: Until funds are depleted.
Award Amount: Loan maximum is 100 percent of the allowable total development cost.
Eligible Entities: Individual farm owners, family farm partnerships, family farm corporations, and associations of farmers.
​Description: It provides affordable financing to develop or rehabilitate affordable rental housing for very-low to moderate income domestic, migrant, and seasonal farm laborers. It also provides funding used to increase the supply of affordable housing for farm labor; and the ability of the farmer to provide affordable, decent, sage and sanitary housing for farm workers.

Deadline: Apply by 11:59pm on the last day of the month to be eligible for that month
Award Amount: $1,000
Match: None
Eligible Entities: 51% women owned, registered in the US, and less than $1 million in gross revenue
Description: The HerRise MicroGrant, providing $1,000 each month, is available to under-resourced women, including women of color entrepreneurs, across a variety of industries. The HerRise MicroGrant offers financial support to innovative women who struggle to secure funding for their community-impacting small businesses. Small business grants are useful for financing a particular small business need. Past recipients used their growth grants for computers, equipment, marketing materials, software purchase, website creation and more.

Deadline: Rolling
Award Amount: Up to $2,500 monthly
Match: None
Eligible Entities: Small Businesses, Nonprofits, Startups
Description: This opportunity awards startup grants of up to $2,500 monthly to entrepreneurs. They also offer additional funding opportunities to registered members, such as one-on-one mentorship, tools and resources, special events, and human support.