Deadline: November 16, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, and Education
Description: The purpose of this notice of funding opportunity is to invite R03 applications to support archiving and documenting existing data sets in order to enable secondary analysis of these data by the scientific community. The priority of this program is to archive data sets within the scientific mission of the NICHD; highest priority is to archive data collected with NICHD support.

Deadline: November 19, 2025
Award Amount: $25,000 to $50,000
Match: Yes
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, and Businesses
Description: Provides grants to support the development and expansion of food-related businesses and infrastructure in underserved communities. The fund aims to strengthen local food systems, increase access to healthy food, and promote economic development in rural and underserved areas of New Mexico.

Deadline: November 28, 2025
Award Amount: $300 to $500,000
Match: None
Eligible Entities: Nonprofits
Description: Supports long-term partnerships with nonprofits that drive community health and well-being through interventions in healthcare, social services, and education. It prioritizes organizations that understand local needs and can grow impact over time, rather than funding one-time events or promotional support.

Deadline: December 1, 2025
Award Amount: Up to $800,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, and Nonprofits
Description: This Notice of Funding Opportunity is intended to support novel environmental health research in which an unpredictable event or policy change provides a limited window of opportunity to collect human biological samples or environmental exposure data. The primary motivation of the NOFO is to understand the consequences of natural and human-made disasters, emerging environmental public health threats, and policy changes in the U.S. and abroad.

Deadline: December 1, 2025
Award Amount: Unspecified
Match: Yes
Eligible Entities: Nonprofits
Description: This program assists individuals with low to moderate incomes in financing certain costs associated with household water wells and septic systems. It provides funding for the construction, repair, or replacement of these systems to ensure access to safe and reliable water sources. The initiative aims to improve public health and environmental quality by supporting sustainable water infrastructure in underserved communities.

Deadline: December 1, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: Nonprofits
Description: Supports nonprofit organizations in New Mexico and Louisiana that promote positive, lasting change through innovative programs and services. Grants focus on human rights, education, animal welfare, and environmental stewardship, prioritizing creativity, collaboration, and community impact.

Deadline: December 2, 2025
Award Amount: $272,255 to $816,750
Match: Yes
Eligible Entities: State, City, Township, County or Tribal Governments and Nonprofits
Description: Supports Public and Indian Housing residents in achieving economic self-sufficiency by funding service coordinators who connect residents to employment, educational, and health services. The goal is to enhance residents’ quality of life and promote long-term independence. Grants are awarded to public housing agencies and tribal entities to facilitate the coordination of these services.

Deadline: December 2, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: Education, Nonprofits, Businesses, State, City, Township, County or Tribal Governments
Description: This Notice of Funding Opportunity invites applications that propose to develop novel research infrastructure that will advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations. This NOFO will use the NIH Phased Innovation Award (R61/R33) mechanism to provide up to 2 years of R61 support for initial developmental activities and up to 3 years of R33 support for expanded activities. Through this award, investigators will develop a sustainable research infrastructure to support projects that address key interdisciplinary aging research questions.

Deadline: December 4, 2025
Award Amount: $500,000 to $30,000,000
Match: None
Eligible Entities: Higher Education and Nonprofits
Description: Supports national-scale data systems and cyberinfrastructure that advance open, AI-driven, and data-intensive science and engineering research and education, including development, transition, and planning of integrated data services.

Deadline: December 5, 2025
Award Amount: $100,000 to $500,000
Match: Yes
Eligible Entities: State, City, Township, County or Tribal Governments and Nonprofits
Description: Supports efforts to improve access to local foods in Child Nutrition Program (CNP) sites through farm-to-CNP initiatives that combine local sourcing with agricultural education. Projects may incorporate locally grown foods into meals, expand infrastructure and distribution capacity, strengthen producer readiness, and create educational opportunities such as school gardens, farmers markets, and curriculum integration. The goal is to connect students with healthy, locally sourced foods while fostering agricultural knowledge, supporting regional producers, and encouraging healthy eating habits.

Deadline: Rolling: June 27, September 19, December 5, April 4.
Award Amount: Dependent upon project.
Match: None
Eligible Entities: Nonprofits
Description: Kroger believes strong communities are everyone’s responsibility. Each year, Kroger helps hundreds of local nonprofit organizations that are working to make our communities better places to live and work.

Kroger is specifically interested in these focus areas: Zero Hunger & Zero Waste, Diversity & Inclusion, Health & Nutrition, Education & Youth Development, Disaster Relief, and Building Stronger Communities.

Deadline: December 9, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Higher Education, Nonprofits, and Business
Description: This program provides funding for three types of awards: standard individual or group research projects, mid-scale research infrastructure, and long-term efforts. It outlines requirements for proposals, including additional instructions for large or long-duration investments that may span multiple funding cycles. The purpose is to support research ranging from typical projects to significant, sustained infrastructure and long-term initiatives.

Deadline: December 31, 2025
Award Amount: Up to $1,000,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments and Nonprofits
Description: This program provides funding to support the development and implementation of sustainable water management practices in rural communities. It focuses on reducing or eliminating pollution of water resources and improving planning and management of water systems. The initiative aims to enhance the quality and availability of water resources through community-driven solutions.

Deadline: December 31, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: Nonprofits
Description: Supports private nonprofit organizations in delivering technical assistance and training to rural communities facing water and wastewater challenges. Recipients will help water/waste associations with problem-identification (e.g. source, treatment, distribution, collection, disposal) and with preparing federal water/waste financing applications. The goal is to strengthen long-term operational capacity and sustainability of rural water/waste systems and to support contamination remediation (e.g. lead, PFAS).

Deadline: December 31, 2025
Award Amount: Up to $1,000,000
Match: None
Eligible Entities: Environment, Education, State, City, Township, County or Tribal Governments, Nonprofits, Business
Description: Supports projects that restore aquatic habitats and improve fish passage by removing or modifying barriers, enhancing species access to critical habitats and promoting fish population conservation.

Deadline: December 31, 2025
Award Amount: Unspecified
Match: None
Eligible Entities: Nonprofits
Description: Supports nonprofit organizations that strengthen diverse communities across the United States. Its funding priorities include expanding access to education, particularly in STEM, early childhood learning, and safety; promoting community engagement through initiatives such as financial literacy, food insecurity, environmental conservation, animal welfare, and health and wellness; and advancing equity, justice, diversity, and inclusion.

Deadline: December 31, 2025
Award Amount: $250,000 to $750,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, K-12 Education, and Nonprofits
Description: Supports nonprofit charter school networks aiming to expand their impact by opening new schools. Through its Seed and Scale strategies, CSGF provides multi-year grants and strategic support to help leaders grow their networks.

Deadline: Rolling: February 1 to April 15, May 1 to July 15, August 1 to October 15, November 1 to December 31
Amount: $250 to $5,000
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, Fire, Public Safety, Education
Description: Walmart aims to support organizations that create opportunity and strengthen their community, and advance sustainability. Examples include creating economic opportunity, preserving nature, reducing plastic, food, and textile waste, easing access to healthier foods, and disaster preparedness and response.

Deadline: January 6, 2026
Award Amount: Up to $300,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, Higher Education, and Water
Description: The Land and Water Conservation Fund Act of 1965 created a matching grant program to stimulate, encourage, and assist states with the acquisition, development, and expansion of quality outdoor recreation areas and facilities. LWCF is a reimbursement grant program funded by revenues generated from outer continental shelf oil and gas drilling.

Deadline: January 8, 2026
Award Amount: $30,000 to $750,000
Match: Yes
Eligible Entities: State, City, Township, County or Tribal Governments and Nonprofits
Description: The American Battlefield Protection Program (ABPP) offers grants to support community-driven stewardship of historic resources through four grant opportunities: Preservation Planning, Battlefield Restoration, and Education and Interpretation. These grants aim to protect and preserve significant battlefields and related historic sites across the United States. Eligible applicants include nonprofit organizations, local governments, and tribal entities involved in the preservation of historic battlefields.

Deadline: January 8, 2026
Award Amount: $150,000 to $250,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, and Nonprofits
Description: This program provides one-year, unrestricted grants along with coaching, expert support, and a national peer network to help early-stage education innovators grow their impact. It funds bold ideas that align with key investment areas such as innovative schools, learning solutions, teaching reimagined, and learning differences. The goal is to expand equitable learning opportunities and create a more just future for students.

Deadline: January 11, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: Higher Education, Nonprofits, Businesses, State, City, Township, County or Tribal Governments
Description: This Notice of Funding Opportunity supports applications to develop and implement investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or implementation research clinical trials. These trials may include ones that test different therapeutic, behavioral, and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial.

Deadline: January 15, 2026
Award Amount: Up to $1,000,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, and Businesses
Description: The CyberTraining program aims to prepare, nurture, and grow the national scientific research workforce for creating, utilizing, and supporting advanced cyberinfrastructure (CI) to enable and potentially transform fundamental science and engineering (S&E) research and education. The program seeks to ensure broad adoption of CI tools, methods, and resources by the research community to catalyze major research advances and to enhance researchers’ abilities to lead the development of new CI.

Deadline: January 15, 2026
Award Amount: $5,000 to $10,000
Match: None
Eligible Entities: Nonprofits
Description: Supports the development, maintenance, and stewardship of trails. Funding can help address the shortfall in Phase One trail construction, expand outdoor recreation infrastructure, and build long-term capacity for trail maintenance and volunteer training. This opportunity directly advances the county’s goal of expanding access to safe, high-quality trails that connect residents to outdoor recreation, improve quality of life, and strengthen community health.

Deadline: January 20, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, Nonprofits, and Businesses
Description: This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS).

This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain.

Deadline: January 21, 2026
Award Amount: Up to $75,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, and Nonprofits
Description: This program aims to prevent and reduce the use of opioids, methamphetamines, and the misuse of prescription drugs among youth aged 12–18. It supports initiatives that provide education, outreach, and intervention strategies to address substance use and promote healthy behaviors. The focus is on implementing evidence-based practices that engage youth and communities in prevention efforts.

Deadline: January 27, 2026
Award Amount: Up to $250,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Nonprofits, Education, and Businesses
Description: Support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. Specifically, this FOA will support the development of exportable training modules designed to enhance training of the biomedical research workforce. Responsive topics will be indicated through Notices of Special Interest released annually by NIGMS.

Deadline: February 4, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: Higher Education, Nonprofits, and Businesses
Description: The National AI Research Resource (NAIRR) program aims to build a shared national infrastructure that expands access to advanced computing, high-quality data, models, software, and training for artificial intelligence research. This Notice of Funding Opportunity invites proposals to operate and coordinate the foundational elements of NAIRR, helping to create a sustainable platform that supports broad participation in AI innovation. Applicants will play a key role in enabling researchers and educators across the country to responsibly advance AI while strengthening U.S. leadership in the field.

Deadline: March 1, 2026
Award Amount: Up to $10,000
Match: None
Eligible Entities: Nonprofits and State, City, Township, County or Tribal Governments
Description: Supports nonprofit organizations and local riding clubs in their efforts to promote safe and responsible off-road recreation. The program provides funding for trail development and maintenance, safety education initiatives, and environmental stewardship projects.

Deadline: March 5, 2026
Award Amount: Up to $250,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Education, Nonprofits, and Businesses
Description: This funding opportunity focuses on biomedical discovery and data-powered health, integrating streams of complex and interconnected research outputs that can be translated into scientific insights, clinical care, public health practices, and personal wellness to ensure the research is scalable, reproducible, and generalizable.

The scope of NLM’s interest in these research domains is broad, with emphasis on new and innovative methods and approaches to foster data driven discovery in the biomedical and clinical health sciences as well as domain-independent, scalable, and reusable approaches to discovery, curation, analysis, organization, and management of health-related data and digital objects.

Deadline: March 6, 2026
Award Amount: Up to $100,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Businesses, Education, Nonprofits, and Businesses
Description: The New Investigator Gateway Award in T1D Research is designed to support a robust pipeline of innovative projects and talented new investigators in T1D research. In addition to providing support for preliminary research, the Gateway program provides an opportunity for new Program Directors/Principal Investigators (PD/PIs) to pursue their studies within the intellectual environment of a select number of large, ongoing collaborative research programs.

Deadline: March 16, 2026
Award Amount: Up to $100,000
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Businesses, Nonprofits, and Education
Description: This Small Research Grant will support meritorious projects to provide needed scientific insight to improve the prevention, diagnosis, treatment, and/or care for individuals with Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). Specifically, this NOFO will support projects covering a wide range of topics related to AD/ADRD. The overall goal of this NOFO is (1) to encourage the next generation of researchers to pursue research and academic careers in AD/ADRD research; and (2) to stimulate established researchers who have not had a major award in AD/ADRD research to perform pilot studies to develop new, innovative AD/ADRD research programs that leverage and build upon their existing expertise.

Deadline: April 14, 2026
Award Amount: Up to $125,000
Match: Yes
Eligible Entities: State, City, Township, County or Tribal Governments and Nonprofits
Description: Supports community-based efforts to prevent and reduce youth substance use, including alcohol, tobacco, and illicit drugs. It provides funding for coalitions that engage multiple sectors, such as schools, law enforcement, and local organizations, to implement evidence-based prevention strategies. The initiative aims to strengthen community capacity and promote sustainable, data-driven approaches to substance misuse prevention.

Deadline: April 28, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: Tribal Governments, Nonprofits, Higher Education, and Businesses
Description: This grant aims to support projects that enhance the safety, security, and privacy of open-source ecosystems, including tools, methods, or processes that protect open source software from abuse, vulnerabilities, or privacy violations. Awards will fund work such as threat modeling, privacy enhancing technologies, secure tooling, and community governance mechanisms to strengthen open source infrastructure.

Deadline: May 7, 2026
Award Amount: Unspecified
Match: None
Eligible Entities: State, City, Township, County or Tribal Governments, Businesses, Nonprofits, and Education
Description: This Trailblazer Award is an opportunity for NIH-defined New and Early Stage Investigators to pursue research programs that integrate engineering and the physical sciences with the life and/or biomedical sciences. A Trailblazer project may be exploratory, developmental, proof of concept, or high risk-high impact, and may be technology design-directed, discovery-driven, or hypothesis-driven.